7/31/2023 0 Comments Yunfeng liu yu binThe DSP1 complex required for snRNA 3' maturation was recently identified in Arabidopsis. ![]() The goal of this project is to better understand plant snRNA 3' maturation. Consequently, the mechanism governing plant snRNA 3' maturation is not clear. The protein factors involved in snRNA 3' end processing were unknown in plants. snRNA 3' maturation evolved differently among metazoans, fungi and plants. snRNA 3' end maturation, which requires cleavage at the 3' end of the primary transcript of snRNAs, is essential for snRNA biogenesis. Consequently, snRNA biogenesis is fundamental to biology. They guide the formation of spliceosome and catalyze the splicing of mRNAs, which is a key step in decoding genetic information stored in the genome and thus they play a crucial role in regulating gene expression. Small nuclear RNAs (snRNAs) are the basal components of the spliceosome. This project also includes an effort to increase diversity in STEM by recruiting and training members of underrepresented groups and first generation students. This project will train students and provide them with skills needed to productively contribute to STEM industries and occupations. The primary goal of this project is to dissect the mechanism governing the biogenesis of small nuclear RNAs, which are core components of the splicing machinery and hence important for gene expression. ![]() Ultimately, this type of information will facilitate the engineering of plants for agricultural production. This project will contribute to fundamental knowledge related to splicing and gene expression in plants. Primary Place of Performance Congressional District:
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